Analytical support to obtain lithium-containing plant extracts of the rhythm-modulating action

Plants are important natural sources of macro - and micronutrients. They are found in plants in optimal proportions in the form of complex organometallic compounds with biologically active substances. This helps their better absorption in the body and leads to a high functional activity. One of such elements is lithium. It releases the magnesium ions from the cellular depot in the body, resulting in reduced speed of transmission of nerve impulses and reduces the excitability of the nervous system. Under the influence of lithium glucose consumption, glycogen synthesis and insulin levels in the serum are increasing. The possibility of correction of DS rhythm «sleep-waking» by vegetative complex of lithium has been established. Some plants are able to selectively accumulate lithium. In the course of study it was revealed that agrimony hairy «Agrimonia pilosa Ledeb» (fam. Rosaceae) is the hubs of lithium. The proposed algorithm of analytical support of drug development is based on the Agrimonia pilosa plant, which includes the definition of not only lithium, but also accompanying elements in objects of plant and animal origin. The approaches to the analysis of plant samples, water extracts, fractions of biologically active substances (BAS) and brain tissue of experimental rats were developed. The results of the research showed pronounced rhythm-modulating activity of aqueous extracts and groups of biologically active substances enriched in lithium have been extracted. A promising group of biologically active substances for further study and creation on their base of the drug with high biological activity has been identified. The work was performed in an accredited Tomsk regional center for shared use (accreditation certificate no. ROSS RU.0001.517686), of National research Tomsk state University (TSU).

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