The use of special electrolytes with co-dissolved biodegradable polymers for the production of bioactive calciumphosphate coatings by microarc oxidation (МАО)

Today, metal implants for various purposes are an integral part of surgical practice in traumatology and orthopedics. Meanwhile, cases of implant rejection are common and the rate of new bone growth on an untreated metal surface is low. The rate of recovery of a patient directly depends on the rate of regeneration of body tissues, and the rate of regeneration is determined by the behavior of cells at the site of surgery. One of the proposed solutions is the use of bioactive coatings that improve the biocompatibility of implants, improve cell proliferation and adhesion. A widespread resource of such coatings is calcium phosphates of various origins, such as ones obtained by micro-arc oxidation. Among the techniques of coating obtainment, a great interest was the method of micro-arc oxidation (MAO). The MAO method allows obtaining porous, rough coating with a specified chemical composition that plays an important role in osteoconductionprocess. However, fragility of obtained coatings is significantly higher than bone fragility. Thus, mechanical inconsistencies may affect on integrity of obtained coating during implantation. The paper proposes a method for the formation of hybrid calcium-phosphate coatings by micro-arc oxidation using an electrolyte based on calcium oxide with an admixture of dispersed particles of hydroxyapatite and co-dissolved biodegradable polymers: chitosan, polyvinylpyrrolidone, and hyaluronic acid. It is assumed that the polymers will act as a plasticizer. The resulting coatings are calcium-deficient and highly porous. It is shown that the introduction of polymers into an electrolyte solution improves the elasticity, specific amount and average pore diameter, and also does not lead to a deterioration in the biocompatibility of coatings.

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