Synthesis, properties of derivatives of a number of cholanic acids and methyl esters

The results of the synthesis of several cholanic acids and methyl esters based on them have been presented. Of particular interest are derivatives of cholanic acids, which have various functional groups and facilitate so the production of several other compounds with desired biological properties on their basis. The behavior of 3α,7β,12α-dihydroxy-5β-cholanic acid in esterification reactions proceeding along the carboxyl group, synthesis of methyl esters has been studied, and the structure of the resulting products has been established. The reactions involving the side chain of cholanic acids include many synthetic transformations, both the modification of the native carboxyl group, leading to the formation of salts, cholanic acids estersf, and the change in the length of the side chain and its functionalization by various transformations.

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