Influence of the compounds enantiomeric form on their biological activity
Prerequisites for the problem. The stereospecificity of the structure of optically active compounds affects their biological activity. Establishing the relationship between stereostroenie (enantiomeric composition) and the bioactivity of molecules is an important task of modern organic and bioorganic chemistry. Purpose: using the example of synthesized monoesters of bicyclo (2.2.1) -hept-5-ene-2,3-dicarboxylic acid to reveal the relationship between the enantiomeric composition of adducts and their biological activity Methodology. The synthesized monoesters of norbornene-dicarboxylic acid, obtained in racemic and optically active forms, were tested as antimicrobial and antifungal drugs by the serial dilution method against gram-positive and gram-negative pathogenic microorganisms. Scientific novelty. Based on the experimental data and test reports approved at the Department of Medical Microbiology of the Azerbaijan Medical University, a relationship was established between the enantiomeric sotav and the biological activity of the synthesized ionesters of norbornene dicarboxylic acid Received data. Based on the tests carried out, it was shown that the optically active form (S-enantiomer) of synthesized monoesters of norbornene dicarboxylic acid has a more pronounced biological activity against pathogenic microorganisms than their racemic form Peculiarities: - studied the antimicrobial and antifungal activity of monoesters of norbornene-dicarboxylic acid. - the results of test tests of the biological activity of the synthesized compounds against pathogenic microorganisms are presented. - the dependence of the bioactivity of the obtained compounds on their enantiomeric composition is shown.
Keywords
monoesters of norbornene-dicarboxylic acid,
diene synthesis,
Staphylococcus aureus,
Escherichia coli,
test cultures,
serial dilution methodAuthors
| Gasanov Arif G. | Institute of Petrochemical Processes, National Academy of Sciences of Azerbaijan | ilgar.ayyubov@mail.ru |
| Ayubov Ilgar G. | Institute of Petrochemical Processes, National Academy of Sciences of Azerbaijan | ilgar.ayyubov@mail.ru |
| Gadzhieva Gulsum E. | Institute of Petrochemical Processes, National Academy of Sciences of Azerbaijan | ilgar.ayyubov@mail.ru |
| Gurbanova Fidan S. | Institute of Petrochemical Processes, National Academy of Sciences of Azerbaijan | ilgar.ayyubov@mail.ru |
Всего: 4
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