Determination of paracetamol by stripping voltammetry on electrodes modified with rare earth elements
The present paper dwells upon the development of a method for the paracetamol determination by stripping voltammetry in solutions. Graphite-containing electrode modified with europium and terbium is proposed to be used as a sensor. The determination is based on the paracetamol with REE ions complex compound formation which adsorbed on the electrode and can be oxidized during anodic potential sweep. The optimal conditions for concentrating and obtaining an analytical signal of paracetamol under the conditions of voltammetry with a linear potential sweep: Ee = -0.9 V, electrolysis time 20 - 120 s were selected, the dependence of the peak current on concentration obeys the equation I = 0.578C - 0.037 (R2 = 0.979). It was proposed to use terbium as a metal for electrode modification. A feasible mechanism for the concentration and oxidation of paracetamol on a modified electrode has been proposed. An algorithm for paracetamol determination by stripping voltammetry (SVA) on a terbium-modified electrode is suggested. The range of determined concentrations of the substance is 0.1-1.5 mg/l. The limit of paracetamol detection is 0,12 mg/l. The approbation of the proposed method for the voltammetric determination of paracetamol was carried out on drugs containing paracetamol. Determination of paracetamol concentration was carried out on drugs such as pentalgin and citramon. The modification of the electrode with terbium showed a higher accuracy of the results of substance determination. Based on the obtained results the authors propose to use terbium as a modifier for carbon-based electrode. Contribution of the authors: the authors contributed equally to this article. The authors declare no conflicts of interests.
Keywords
electrochemical methods of analysis,
stripping voltammetry,
modified electrodes,
paracetamol,
rare earth elementsAuthors
| Kinsfator Anastastasia O. | Tomsk State University | kinsfator_anastasia@mail.ru |
| Shelkovnikov Vladimir V. | Tomsk State University | shvv@chem.tsu.ru |
Всего: 2
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