Macrophages and anti-tuberculosis immunity (literature review)
This literature review is devoted to the analysis of the role of macrophages and monocytes in the immunopathogenesis of tuberculosis infection. The article summarizes information about the origin of macrophages and monocytes, their phenotypic and functional heterogeneity. The mechanisms of impaired protective function of innate immunity are associated with the polarization of the program of maturation and activation of macrophages in the direction to tolerogenic or immunoregulatory cells with phenotype of M2. Alveolar macrophages perform a variety of functions (from proinflammatory to regenerative) in the development of inflammation in the respiratory organs. Their inherent plasticity suggests that the same macrophages can change their phenotype and function depending on the microenvironment in the inflammatory focus at different stages of the disease. Understanding the mechanisms that regulate macrophage plasticity will be an important step towards realizing the potential of personalized immunomodulatory therapy. Contribution of the authors: the authors contributed equally to this article. The authors declare no conflicts of interests.
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Keywords
macrophages, monocytes, alveolar macrophages, lung diseases, innate immunity, immune responseAuthors
| Name | Organization | |
| Churina Elena G. | Tomsk State University; Siberian State Medical University | lena1236@yandex.ru |
| Popova Angelica V. | Siberian State Medical University | anjelika.sitnikova@yandex.ru |
| Urazova Olga I. | Siberian State Medical University | urazova 72@yandex.ru |
| Kononova Tatiana E. | Siberian State Medical University | kononova.te@gmail.com |
| Voronova Gulnara A. | Tomsk State University | gulnara.voronova@mail.tsu.ru |
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Macrophages and anti-tuberculosis immunity (literature review) | Vestnik Tomskogo gosudarstvennogo universiteta. Chimia – Tomsk State University Journal of Chemistry. 2022. № 26. DOI: 10.17223/24135542/26/3
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