USING POLYACRYLAMIDE GEL FOR INJECTION THERA PY OF GASTROESOPHAGEAL REFLUX DISEASE IN EXPERIMENT | Issues of reconstructive and plastic surgery. 2014. № 1(48).

USING POLYACRYLAMIDE GEL FOR INJECTION THERA PY OF GASTROESOPHAGEAL REFLUX DISEASE IN EXPERIMENT

A set of experiments was performed aimed at substantiating possibility of usage of polyacrylamide gel for gastroesophageal reflux treatment. Morphologic changes of rats’ esophagus walls were examined in 1, 3, 7, 14, 21, 45, 90 days after hydrogel DAM+ injections in submucosal layer. These experiments were made on 31 reproductive female rats of Wistar line. Morphometric analysis of result obtained showed that in 24 hours after the surgery, total number of cells increased in submucosal esophagus wall at the expense of macrophagocytes, neutrophils and lymphocytes. Subsequently, total number of cells in submucosal esophagus wall and content of other separate cellular forms did not differ from control. No damaging or local irritating effect of used preparation on esophageal tissues of laboratory rats was revealed. Hydrogel boluses create additional volume in esophageal gaps due to thickening submucosal layer. The data received during the experiment give evidence of possibility of hydrogel DAM+ usage for correction of esophagogastric junction failure in patients having gastroesophageal reflux disease.

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Keywords

polyacrylamide gel, esophagus, gastroesophageal reflux disease, полиакриламидный гель, пищевод, гастроэзофагеальная рефлюксная болезнь

Authors

Name	Organization	E-mail
Balaganski D.A.		tempera@rambler.ru
Koshel A.P.
Fomina T.I.
Souslov I.I.

Всего: 4

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