RA DIO-FREQUENCY ABLATION IN SOLITARY TUMOURS IN THE EXPERIMENT | Issues of reconstructive and plastic surgery. 2014. № 1(48).

RA DIO-FREQUENCY ABLATION IN SOLITARY TUMOURS IN THE EXPERIMENT

The experimental study was performed on 45 mice having Lewis pulmonary carcinoma aimed at studying antitumor and anti-metastasis influence of radiofrequency currents with several exposition time. On the 10 day of bandaging, the animals were divided into 3 groups: animals with tumors without influence (control, n=15), animals with single influence using 2 electrodes (the 1-st group, n=15), animals with single influence using 4 electrodes ( the 2-nd group, n=15). The experiment duration was 21 days. The experiment results showed that influence of radiofrequency currents using 4 electrodes on primary tumor in one time results in reliable (p<0.05) inhibition of primary tumoral node increasing and in increasing number of latest metastases. The data obtained demonstrate perspectivity of using radiofrequency ablation in patients having primary and metastatic tumors of the liver both for tumors therapy and prevention of latest metastasing.

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Keywords

metastatic cancer, radio-frequency termoablation, метастазы рака, радиочастотная термоаблация

Authors

Name	Organization	E-mail
Koshel A.P.		apk@gastro.tomsk.ru
Zuyeva Ye.P.
Klokov S.S.
Tolstykh A.S.
Martynyuk A.K.
Azanov A.Z.

Всего: 6

References

McGahan J.P., Browning P.D., Brock J.M., Tesluk H. Invest Radiol, 1990, Vol. 25, Pp. 267-270.

Steeves R.A. Bull NY Acad Med., 1992, Vol. 68, Pp. 341-350.

McGahan J.P., Brock J.M., Tesluk H., Gu W.Z., et al. J Vasc Interv Radiol.,1992, Vol. 3[2], Pp. 291-297.

Mayo J.G. Cancer Chemother. Rep., 1972, Vol. 3, № 1, Pp. 325-330.

Lee M.E., Curley S.A., Tanabe K.K. Radiofrequence ablation for cancer. Springer-Verlag, New York, Inc.- 2004.-307 p.

Iannitti D.A. Arch. Surg, 2002, Vol. 137, Pp. 422-426.

European Convention for the Protection of Vertebrate Animals used for Experimental and other scientific purposes. - Strasburg: Council of Europe, 1986. - 51 p.

Eddie K. Abdalla, Rene Adam et el. Annals of Surgical Oncology, Vol. 13(10). Pp. 1271-1280.

Curley S.A., Izzo F., Delrio P., et al. Ann Surg.,1999, Vol. 230, N1, Pp. 1-8.

Clavien P.-A., Petrowsky H. et al. N Engl J Med., 2007, Vol. 356, №15, p. 1545-59.

Buscarini L., Buscarini E., Di Stasi M. et al. Ultraschall Med., 1999, Vol. 20 (2), Pp. 47-53.

Bloomston M., Binitie O., Fraiji E. et al. Am Surg, 2002, Vol. 68, Pp. 827-831.

Bilchik A.J., Wood T.F., Allegra D.P. Oncologist, 2001, 6, Pp. 24-33.

Beaugrand M., N’kontchou G., Seror O. et al. Semin. Liver Dis., 2005, 25(2), Pp. 201-211.

Sofyina Z.P. et al. Experimental assessment of anti-tumour drugs in USSR and USA. Мoscow, Meditsina Publ., 1980, 296 p. ( in Russian).

Fedorov V.D., Vishnevski V.A., Kybyshkin V.A. et al. Using radiofrequency ablation device in resection of the liver.Surgery, 2004, №5, Pp. 21-25 (in Russian).

Polyakov A.N. Combined treatment of colorectal cancer metastases into the liver.Author. dis. cand. med. sci. Мoscow, 2009,26 p. ( in Russian).

Patyutko Yu.I. Surgical treatment of malignant tumors of the liver. In: Practical medicine, Moscow, 2005, 312 p. (in Russian).

Vishnevski V.A., Fedorov A.V., Ionkin D.A. et al. Surgery, 2010, №2, Pp. 18-29 ( in Russian).

Goubler Ye.V. Calculating methods of analysis and recognizing pathologic processes. Leningrad, 1978, 193 p. (in Russian).

Naberezhnev D.I. Radiofrequency thermoablation in combined therapy of patients with metastases of colorectal cancer into the liver (experimental-clinical study). Author. dis cand. med. sci. Voronezh, 2009, 24 p. (in Russian).

Steeves R.A. Hypertermia in cancer therapy: where are we today and where are we going? // Bull NY Acad Med. - 1992. - V. 68. - P. 341-350.

Аrkhipov S.A., Yunker V.M.Changing intensity of matastasing into lungs of mice’ neoplasms in dependence on quantity of neoplasmatic cells dose. In: Study on induction and metastasing of neoplasms in experimental animals. Novosibirsk, 1984. Pp. 14-32 (in Russian).

McGahan J.P., Brock J.M., Tesluk H., Gu W.Z., et al. Hepatic ablation with use of radio-frequency electrocautery in the animal model // J Vasc Interv Radiol. - 1992. - V. 3[2]. - 291-297.

McGahan J.P., Browning P.D., Brock J.M., Tesluk H. Hepatic ablation using radiofrequency electrocautery. Invest Radiol 1990; 25: 267-270

Iannitti D.A. Hepatic radiofrequency ablation // Arch. Surg. - 2002. - Vol. 137. - P. 422-426.

Lee M.E., Curley S.A., Tanabe K.K. Radiofrequence ablation for cancer \\ Springer-Verlag, New York, Inc. - 2004. - 307 p.

Mayo J.G. Biological characterization of the subcutaneously implanted Lewis lung tumor // Cancer Chemother. Rep. - 1972. - V. 3. - № 1. - P. 325-330.

European Convention for the Protection of Vertebrate Animals used for Experimental and other scientific purposes. - Strasburg: Council of Europe, 1986. - 51 p.

Curley S.A., Izzo F., Delrio P., et al. Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies: results in 123 patients // Ann Surg. -1999. - V. 230[1]. - P. 1-8.

Eddie K. Abdalla, Rene Adam et el. Improving Respectability of Hepatic Colorectal Metastases: Expert Consensus Statement. Annals of Surgical Oncology. - V. 13(10). - P. 1271-1280.

Clavien P.-A., Petrowsky H.et al. Strategies for Safer Liver Surgery and Partial Liver Transplantation. N Eng.l. J Med. - 2007. - Vol. 356. - № 15. - P. 1545-59.

Buscarini L., Buscarini E., Di Stasi M. et al. Percutaneous radiofrequency thermal ablation combined with transcatheter arterial embolization in the treatment of large hepatocellular carcinoma. // Ultraschall Med. - 1999. - V. 20 (2). - P. 47-53.

Bilchik A.J., Wood T.F., Allegra D.P. Radiofrequency ablation of unresectable hepatic malignancies: lessons learned // Oncologist. - 2001. - 6. - P. 24-33.

Bloomston M., Binitie O., Fraiji E. et al. Transcatheter arterial chemoembolisation with or without radiofrequency ablation in the management of patients with advanced hepatic malignancy // Am. Surg. - 2002. - V. 68. - P. 827-831.

Beaugrand M., N’kontchou G., Seror O., et al. Local/regional and systemic treatments of hepatocellular carcinoma // Semin Liver Dis. - 2005. - 25(2). - P. 201-211.

Федоров В.Д., Вишневский В.А. Кубышкин В.А., Корняк Б.С., Икрамов Р.З., Гаврилин А.В., Щеголев A.И., Сергеева О.Н., Ионкин Д.А., Тарасюк Т.И. Использование аппарата радиочастотной аблации при резекции печени // Хирургия. 2004. - № 5. - С. 21-25.

Поляков А.Н. Комбинированное лечение метастазов колоректального рака в печени: автореф. дисс. … канд. мед. наук. - М., 2009. - 26 с.

Софьина З.П. и др. Экспериментальная оценка противоопухолевых препаратов в СССР и США. - М.: Медицина, 1980. - 296 с.

Патютко Ю.И. Хирургическое лечение злокачественных опухолей печени. - М.: Практическая медицина, 2005. - 312 с.

Набережнев Д.И. Радиочастотная термоаблация в комбинированном лечении пациентов с метастазами колоректального рака в печень (экспериментально-клиническое исследование) / Автореф. дисс… канд. мед. наук. - Воронеж, 2009. - 24 с.

Гублер Е.В. Вычислительные методы анализа и распознавания патологических процессов. - Л., 1978. - 193 с.

Вишневский В.А., Федоров А.В., Ионкин Д.А. и др. Осложнения радиочастотной термоаблации злокачественных новообразований печени // Хирургия. - 2010 - №2. - С. 18 - 29.

Архипов С.А., Юнкер В.М. Изменение интенсивности метастазирования в легкие перевиваемых опухолей мышей в зависимости от величины перевивочной дозы опухолевых клеток // Исследование по индукции и метастазированию опухолей у экспериментальных животных. - Новосибирск, 1984. - С. 14-32.