USING NEURONAL POLYSSACHARIDE MATRIXIN THE TREATMENT OF EXPERIMENTAL SPINAL CORD INJURY | Issues of reconstructive and plastic surgery. 2012. № 1 (40).

USING NEURONAL POLYSSACHARIDE MATRIXIN THE TREATMENT OF EXPERIMENTAL SPINAL CORD INJURY

The aim of the work is to show processes of embryonic stem cells proliferation and differentiation to neuronal rateon collagen-chitosan matrix at the presence of artificial conditioned neuronal nutrient medium and differentiatedneuronal factors, to show practical use of the specialized scaffolds for bioengineering of a spinal cord in experimentalspinal trauma at rats by direct transplantation in a zone of breaking.

Download file

Counter downloads: 224

Keywords

нейрональная матрица, эмбриональная стволовая клетка, предшественники нейрональных кле- ток, экспериментальная спинальная травма, нейрональные маркеры, трансплантация, биоинженерия спинного мозга, неврологический статус, иммуноцитогистохимия, neuronal matrix, embryonal stem cell, predecessors neuronal cells, experimental spinal cord injury, neuronal markers, transplantation, bioengineering of a spinal cord, neurologic status, immuno-cyto-histochemistry

Authors

Name	Organization	E-mail
Bolshakov I. N.		e-mail: bol.bol@mail.ru
Eremeev A. V.
Svetlakov A. V.
Sheina Ju. I.
Rendashkin I. V.
Polstjanoi A. M.
Krivopalov B. A.
Kaptjuk G. I.
Karapetjan A. M.
Ignatov A. V.
Medvedeva N. N.
Zhukov E. L.

Всего: 12

References

Kakulas B. A. Neuropathology: the foundation for new treatments in spinal cord injury // Spinal Cord. - 2004. - Vol. 42. - № 10. - P. 549-563.

Young W. Bases for Hope in Spinal Cord Injury. - URL: http://sci.rutgers.edu.

Tsai E. C., Tator C. H. Neuroprotection and regeneration strategies for spinal cord repair // Curr Pharm Des. - 2005. - Vol. 11. - № 10. - P. 1211-1222.

Tator C. H. Strategies for recovery and regeneration after brain and spinal cord injury // Inj. Prev. - 2002. - Vol. 8. - P. 33-36.

Xu X. M., Chen A., Guenard V. et al. Bridging Schwann cell transplants promote axonal regeneration from both the rostral and caudal stumps of transected adult rat spinal cord // J. Neurocytol. - 1997. - Vol. 26. - P. 16.

Weider N., Blesch A., Grill R. J., Tuszynski M. H. Nerve growth factor-hypersecreting Schwann cell grafts augment and guide spinal cord axonal growth and remyelinate central nervous system axons in a phenotypically appropriate manner that correlates with expression of L1 // J. Comp. Neurol. 1999. - Vol. 413. - P. 449-506.

Menei P., Montero-Menei C., Whittemore S. R. et al. Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord // Eur. J. Neurosci. - 1998. - Vol. 10. - P. 607-621.

Sayers S. T., Khan N., Ahmed Y. et al. Preparation of brain-derived neurotrophic factor- and neurotrophin-3-secreting Schwann cells by infection with a retroviral vector // J. Mol. Neurosci. - 1998. - Vol. 10. - P. 143-160.

McDonald J. W., Liu X. Z., Qu Y. et al. Transplanted embryonic stem cells survive, differentiate, and promote recovery in injured rat spinal cord // Nat. Med. - 2000. - Vol. 5. - P. 1410-1412.

Diener P. S., Bregman B. S. Fetal spinal cord transplants support the development of target reaching and coordinated postural adjustments after neonatal cervical spinal cord injury // J. Neurosci. - 1998. - Vol. 18. - P. 763-776.

Das G. D. Neural transplantation in the spinal cord of adult rats. Conditions, survival, cytology and connectivity of the transplants // J. Neurol. Sci. - 1983. - Vol. 62. - P. 191-210.

Bernstein J. J., Underberger D., Hoovler D. W. Fetal CNS transplants into adult spinal cord: techniques, initial effects and caveats // Cent. Nerv. Syst. Trauma. - 1984. - Vol. 1. - P. 39-46.

Theele D. P., Schrimsher G. W., Reier P. J. Comparison of the growth and fate of fetal spinal iso- and allografts in the adult rat injured spinal cord // Exp. Neurol. - 1996. - Vol. 142. - P. 128-143.

Thomson J. A., Itskovitz-Eldor J., Shapiro S. S. et al. Embryonic stem cell lines derived from human blastocysts // Science. - 1998. - Vol. 282. - № 5391. - P. 1145-1147.

Hee Sun Kima, Sun Kyung Oha, Yong Bin Parkb et al. Methods for Derivation of Human Embryonic Stem Cells // Stem Cells. - 2005. - Vol. 23. - № 9. - P. 1228-1233.

Салмина А. Б., Шнайдер Н. А., Михуткина С. В. и др. Изменение активности АДФ-рибозилциклазы в клетках нервной системы коррелирует с развитием постишемической когнитивной дисфункции // Международный неврологический журнал. - 2007. - Т. 1. - №11.

Еремеев А. В., Светлаков А. В., Большаков И. Н. и др. Функции культивируемых эмбриональных клеток на коллаген- хитозановой матрице // Ж. Клеточная трансплантология и тканевая инженерия. - 2009. - Т. IV. - № 2. - С. 55-62.