MOLECULAR GENETIC PROGNOSIS ASSESSMENT OF NON-SPECIFIC INFLAMMATORY BOWEL DISEASES SURGICAL TREATMENT | Issues of reconstructive and plastic surgery. 2014. № 4 (51).

MOLECULAR GENETIC PROGNOSIS ASSESSMENT OF NON-SPECIFIC INFLAMMATORY BOWEL DISEASES SURGICAL TREATMENT

This work presents the results of pathogenetic, clinical diagnostic and prognostic significance of genes’ nucleotide polymorphism connected with nonspecific inflammatory bowel disease for the surgery prognosis evaluation. It is determined that the most perspective are nucleotide polymorphism of genes NOD2 and TNF.. The identification of those genes’ nucleotide polymorphism will afford to forecast objectively the necessity and effectiveness of surgery including surgical recurrence at inflammatory bowel diseases.

Download file

Counter downloads: 364

Keywords

surgery treatment, Crohn’s disease, ulcerative colit, TNF-, NOD2, хирургическое лечение, язвенный колит, Болезнь Крона, NOD2, TNF

Authors

Name	Organization	E-mail
Kuznetsova D. A.
Merzlyakov M. V.		merzliakow@mail.ru
Razumov A. S.

Всего: 3

References

Alvarez-Lobos M., Arostegui J. I. , Sans M. et al. // J. Annals of Surgery. 2005; 242(5): 693-700.

Radlmayr M., Torok H.P., Martin K., et al. The c-insertion mutation of the NOD2 gene is associated with fistulizing and fibrostenotic phenotypes in Crohn’s disease // Gastroenterology. 2002; 122: 2091-2092.

Bidwell J., Keen L., Gallagher G. et al. Cytokine gene polymorphism in human disease: on-line databases // Genes and Immunity. - 1999, № 1. - P. 3-19. GeneCard for gene TNF // http://bioinfo.weizmann.ac.il/cards-bin/carddisp?TNF.

Ferguson L.R., Huebner C., Petermann I. et al. Single nucleotide polymorphism in the TNF. gene affects inflammatory bowel diseases risk // World J. Gastroenterol., 2008; 14(29): 4652-4661.

Sykora J., Subrt I., Didek P. et al. Cytokine TNF-. A promoter gene polymorphism at position -308 G.A and pediatric inflammatory bowel disease: implications in ulcerative colitis and Crohn’s disease // J. Pediatr. Gastroenterol. Nutr. 2006; 42: 479-487.

Cucchiara S., Latiano A., Palmieri O. et al. Polymorphisms of TNF-. but not MDR1 influence response to medical therapy in pediatric-onset inflammatory bowel disease // J. Pediatr. Gastroenterol. Nutr. 2007; 44: 171-179.

Hampe J., Grebe J., Nikolaus S., et al. Association of NOD2 (CARD 15) genotype with clinical course of Crohn’s disease: a cohort study // Lancet. 2002. 359: P. 1661-1665.

Lesage S., Zouali H., Cezard J. P., et al. CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J. Hum. Genet. 2002; 70: 845-857.

Van Heel D. A., Fisher S. A., Kirby A. et al. Inflammatory bowel disease susceptibility loci defined by genome scan meta.analysis of 1952 affected relative pairs // Human Molecular Genetics. 2004. 13(7): 763-770.

Abreu M. T., Taylor K. D., Lin Y. C., et al. Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn’s disease // Gastroenterology. 2002;123: 679-688.

Ahmad T., Armuzzi A., Bunce M., et al. The molecular classification of the clinical manifestations of Crohn’s disease // Gastroenterology. 2002; 122: 854-866.

Cuthbert A. P., Fisher S. A., Mirza M. M., et al. The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease // Gastroenterology. 2002; 122: 867-874.

Inoue N., Tamura K., Kinouchi Y. et al. Lack of common NOD2 variants in Japanese patients with Crohn’s disease // J. Gastroenterology. - 2002. - V. 123. - P. 86-91.

Hampe J., Cuthbert A., Croucher P. J. et al. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations // Lancet. 2001. 357: P. 1925-28.

Baeuerle P., Henkle T. Function and activation of NF-kB in immune system // Annual Rev. Immunol. - 1994. - V. 12. - P. 141-179.

Van Limbergen J., Wilson D. C., Satsangi J. The Genetics of Crohn’s Disease // J. Genomics and Human Genetics. 2009; V. 10: 89-116.

Farrokhyar F., Swarbrick E., Grace R. et all. Low mortality in ulcerative colitis and Crohn’s disease in three regional centers in England // Am J. Gastroenterol.;1996: 501-507.

Никулина И.В., Златкина А.Р., Белоусова Е.А., Румянцев В.Г., Юрков М.Ю. Оценка клинико-эпидемиологических показателей воспалительных заболеваний кишечника в Московской области // РЖГГК. - 1997. - № 2. - С. 67-71.

Franke A., McGovern D. P., Barrett J. C. et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn’s disease susceptibility loci // J. Nature genetics 2010; 42 (12): 1118-1125.

Ekbom A. The IBD epidemiology // A report from the 1-st International meeting on chronic Inflammatory Bowel Diseases. - Madrid. - 2000. - May, P. 4-5.

Shivanada S., Lennard-Jones J., Logan R. Incidence of inflammatory bowel disease across Europe: is there a difference between North and South? (Results of the European Collaborative Study of the Inflammatory Bowel Disease EC - IBD) // Gut. - 1996. - 39 (5). - P. 690-697.

Халиф И. Л., Лоранская И. Д. Воспалительные заболевания кишечника (неспецифический язвенный колит и болезнь Крона): клиника, диагностика и лечение. М.: Миклош. - 2004. - 88 c.

Munkholm P., Langholz E., Nielsen J. H., et al. Incidence and prevalence of Crohn’s disease in the county of Copenhagen, 1962-87: a sixfold increase in incedence. Scand. J. Gastroenterol. 1992,(27): 609-614.