INHIBITION OF SIGNALING CASCADE OF GROUP P38 MITOGEN-ACTIVATED PROTEIN KINASE AS A NEW PROMISE FOR IMPROVEMENT OF QUALITY OF POSTOPERATIVE SCARS | Issues of reconstructive and plastic surgery. 2018. № 4 (67). DOI: 10.17223/1814147/67/02

INHIBITION OF SIGNALING CASCADE OF GROUP P38 MITOGEN-ACTIVATED PROTEIN KINASE AS A NEW PROMISE FOR IMPROVEMENT OF QUALITY OF POSTOPERATIVE SCARS

The paper is devoted to the problem of scar formation in the practice of a plastic surgeon. It is obvious that progress in surgical technology will not lead to disappearance of the problem of marked scars. To achieve a quantum leap, new fundamental knowledge about mechanisms of inflammation and formation of connective tissue is needed. The paper presents data on the ways of activation and functioning of mitogen-activated protein kinase (MAPK). The particular attention is paid to the p38 MAPK family. The influence on these signaling cascades is considered as a promising action on the growth of connective tissue. The possibility of controlling the growth of connective tissue by affecting MAP-kinase cascades is proved. Prolonged blockade of p38 MAPK decreases the width and density of collagenous fibers in the zone of formation of a postoperative scar. The use of stimulators and blockers of MAP-kinase mechanisms is promising as a new field in plastic surgery.

Download file

Counter downloads: 110

Keywords

митогенактивируемая протеинкиназа, р38 МАРК, ингибитор р38 МАРК, соединительная ткань, mitogen-activated protein kinase, p38 MAPK, p38 MAPK inhibitor, connective tissue

Authors

Name	Organization	E-mail
Zelenin N.V.	Irkutsk Scientific Center of Surgery and Traumatology	Zelenin.med@gmail.com
Manturova N.E.	N. I. Pirogov Russian National Research Medical University
Shurygin M.G.	Irkutsk Scientific Center of Surgery and Traumatology
Granina G.B.	Irkutsk Scientific Center of Surgery and Traumatology
Umanets V.A.	Irkutsk Scientific Center of Surgery and Traumatology
Shurygina I.A.	Irkutsk Scientific Center of Surgery and Traumatology

Всего: 6

References

Rohrich R.J. The “Current Concepts in Wound Healing: Update 2016” Supplement. Plastic and Reconstructive Surgery. 2016; 138 (3S): 7-8. doi: 10.1097/PRS.0000000000002693.

Boo S., Dagnino L. Integrins as modulators of transforming growth factor beta signaling in dermal fibroblasts during skin regeneration after injury. Adv. Wound Care (New Rochelle). 2013; 2(5): 238-246.

Greaves N.S., Ashcroft K.J., Baguneid M., Bayat A. Current understanding of molecular and cellular mechanisms in fibroplasia and angiogenesis during acute wound healing. J. Dermatol. Sci. 2013; 72 (3): 206-217.

Marshall C.D., Hu M.S., Leavitt T. et al. Cutaneous scarring: basic science, current treatments, and future directions. Adv. Wound Care (New Rochelle). 2018; 7 (2): 29-45. doi: 10.1089/wound.2016.0696.

Wang P.H., Huang B.S., Horng H.C., Yeh C.C. et al. Wound healing. J. Chin. Med. Assoc. 2018; 81 (2): 94-101. doi: 10.1016/j.jcma.2017.11.002.

Шурыгина И.А., Шурыгин М.Г., Зеленин Н.В., Гранина Г.Б. Роль MAP-киназных механизмов в регуляции клеточного роста (обзор литературы). Сибирский медицинский журнал (Иркутск). 2009; 89 (6): 36-40.

Greenblatt M.B., Kim J.M., Oh H. et al. P38 MAPK is required for tooth morphogenesisand enamel secretion. J Biol Chem. 2015; 290 (1): 284-295.

Dong S., Sun Y. MicroRNA-22 may promote apoptosis and inhibit the proliferation of hypertrophic scar fibroblasts by regulating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase/p21 pathway. Exp. Ther. Med. 2017; 14 (4: 3841-3845. doi: 10.3892/etm.2017.4942.

Лекарственная пленка пролонгированного действия, способ изготовления и способ ее применения: Пат. 2445074 Рос. Федерация; МПК A61K 9/00 (2006.01), A61K 47/10 (2006.01), A61K 47/38 (2006.01), A61P 17/02 (2006.01). М.Г. Шурыгин, И.А. Шурыгина; заявитель и патентообладатель Учреждение Российской академии медицинских наук Научный центр реконструктивной и восстановительной хирургии Сибирского отделения РАМН. № 2010127029/15, заявл. 01.07.2010; опубл. 20.03.2012. Бюл. № 8.

Cheng Y., Prusoff W.H. Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochem. Pharmacol. 1973; 22(23): 3099- 3108.

Davies S.P., Reddy H., Caivano M., Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 2000; 351 (Pt 1): 95-105.

Волкова О.В., Елецкий Ю.К. Основы гистологии с гистологической техникой. М.: Медицина. 1982. 302 с.

Bancroft J.D., Gamble M. Theory and practice of histological techniques. Elsevier Health Sciences. 2008: 725 p.

Способ определения относительной площади волокон коллагена в гистологическом препарате: Пат. 2332665 Рос. Федерация: МПК G01N33/48 (2006.01). М.Г. Шурыгин, Н.Н. Дремина, И.А. Шурыгина, И.Н. Мачхин, С.Л. Антипина; заявитель и патентообладатель ГУ Науч. центр реконструктивной и восстановительной Пластическая хирургия 19 Вопросы реконструктивной и пластической хирургии № 4 (67) декабрь’ 2018 хирургии ВСНЦ СО РАМН. № 2006142273/15; заявл. 29.11.06; опубл. 27.08.08. Бюл. № 24

Миронов А.А., Комиссарчик Я.Ю., Миронов В.А. Методы электронной микроскопии в биологии и медицине. СПб.: Наука, 1994. 400 с.