EMBRIOGENESIS OF UPPER LIMB: FROM TUBERCLE TO INCREASINGLY COMPLEX MECHANISM | Issues of reconstructive and plastic surgery. 2018. № 4 (67). DOI: 10.17223/1814147/67/07

EMBRIOGENESIS OF UPPER LIMB: FROM TUBERCLE TO INCREASINGLY COMPLEX MECHANISM

Throughout the existence of human race, people face congenital malformations of limbs. However, in the last few decades, owing to the progress achieved in genetics and embryology, the understanding of causes and mechanisms of formation of congenital defects has become much better. The paper considers main mechanisms responsible for the normal development of upper limb, whose malfunctioning leads to the births of children with congenital hand defects.

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Keywords

генетика, эмбриология, пороки кисти, врожденные пороки, синдактилия, полидактилия, косорукость, брахидактилия, genetics, embryology, hand deficiency, congenital defects, syndactyly, polydactyly, clubhand, brachydactylia

Authors

Name	Organization	E-mail
Zavarukhin V.I.	St. Petersburg State University’s Clinic of High Medical Technologies named after N.I. Pirogov	zavarukhin.md@gmail.com

Всего: 1

References

Webster W.S. Teratogen update: congenital rubella. Teratology. 1998; 58: 13-23.

Википедия - свободная энциклопедия [Электронный ресурс]. URL: https://ru.wikipedia.org/wiki/Талидомид (дата обращения: 03.01.2017).

Mundlos S., Horn D. Limb malformations. An atlas of Genetic Disoders of Limb Development. Springer-Verlag Berlin Heidelberg, 2014: 267 р.

Zaleske D.J. Development of the upper limb. Hand Clin. 1985; 1: 383-390.

Al-Qattan M., Al-Thunayan A., De Cordier M. et al. Classification of the mirror hand- multiple hand spectrum. J. Hand Surg. 1998; 23B (4): 534-536.

Minguillon C., Nishimoto S., Wood S. et al. Hox genes regulate the onset of Tbx5 expression in the forelimb. Development. 2012; 139: 3180-3188.

Nishimoto S., Wilde S.M., Wood S. RA Acts in a Coherent Feed-Forward Mechanism with Tbx5 to Control Limb Bud Induction and Initiation. Cell Reports. 2015; 12 (5): 879-891.

Ohuchi H. et al. Correlation of wing-leg identity in ectopic FGF-induced chimeric limbs with the differential expression of chick Tbx5 and Tbx4. Development. 1998; 125: 51-60.

Rodriguez-Esteban C., Tsukui T., Yonei S. et al. The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity. Belmonte Nature. 1999; 398: 814-818.

Kozin S.H. Embryology of Congenital Differences. J. Pediatr. Orthop. 2010; 30 (2): S31-S34.

Johnson R.L., Tabin C.J. Molecular models for vertebrate limb development. Cell. 1997; 90: 979-990.

Kelley R.O., Fallon J.F. Ultrastructural analysis of the apical ectodermal ridge during vertebrate limb morphogenesis. II. Gap junctions as distinctive ridge structures common to birds and mammals. Dev Biol. 1976; 51: 241-256.

Saunders J.W., Gasseling M.T. Ectodermal-mesenchymal interactions in the origin of limb asymmetry. In: Fleischmeyer R., Billingham R.E., ed. Epithelial mesenchymal interactions ed. Baltimore: Williams & Wilkins. 1968: 78-97. Реконструктивная хирургия 67 Вопросы реконструктивной и пластической хирургии № 4 (67) декабрь’ 2018

Moskalewski S., Hyc A., Jankowska-Steifer E., Osiecka-Iwan A. Formation of synovial joints and articular cartilage. Folia Morphol. 2013; 72 (3): 181-187.

Mooney A.E.K., Editor C., Molnar J.A. Hand Embryology: Gross Morphologic Overview of Upper Limb Development. Medskape [Электронный ресурс]. URL: emedicine.medscape.com/article/1287982-overview. 2013: 1- (дата обращения: 03.01.2017).

Tonkin M.A., Oberg K.C. The OMT Classification of Congenital Anomalies of the Hand and Upper Limb. Hand Surgery. 2015; 20 (03): 336-342.