MODELING OF PLASTICS OF EPITHELIAL DEFECT OF TRACHEA WALLS USING CELL-ENGINEERING DESIGNS AND STENT
The paper presents the results of experiment on the animal model. Purpose. In the experiment, a new method of plasticizing the epithelial defect of the tracheal wall with a scaffold fixed in the tracheal lumen by means of a vascular stent was developed. Экспериментальная хирургия / Experimental surgery 49 Issues of Reconstructive and Plastic Surgery No. 2 (69) June’ 2019 Material and methods. Тhe object of the study were chinchilla rabbits. The basis experience put the creation of the defect of the epithelium of the wall of the trachea with subsequent to the closing of the cell-engineering design. Two variants of matrix fixation are considered: 1-suturing the scaffold to the tracheal wall, 2-intra-tracheal stent installation simultaneously between inhalation and exhalation of the rabbit under vision control. Results. In the experiment, the advantage of fixation of the matrix by a stent in comparison with the use of suture material becomes obvious. Intra-tracheal stent allows you to open an additional lumen of the trachea and not to spend time on suturing the matrix. In the experiment, the absolute viability of the whole tissue-engineered mucosa of the recipient on a polymer basis was achieved. Conclusions. The proposed method can be applied in clinical conditions. The method can be used as a methodological basis for further work in the field of bioengineering of the lower respiratory tract and any other tubular organs.
Keywords
реконструктивно-восстановительная хирургия,
клеточно-инженерные конструкции,
скаффолд,
стент,
животная модель,
reconstructive surgery,
cell-engineering structures,
scaffold,
stent,
animal modelAuthors
| Denisova A.V. | I.М. Sechenov First Moscow State Medical University (Sechenov University) | denisova-doc@mail.ru |
| Dydykin S.S. | I.М. Sechenov First Moscow State Medical University (Sechenov University) | |
| Safronova Ye.I. | I.М. Sechenov First Moscow State Medical University (Sechenov University) | |
| Piskunova N.N. | I.М. Sechenov First Moscow State Medical University (Sechenov University) | |
| Panteleev A.A. | I.М. Sechenov First Moscow State Medical University (Sechenov University) | |
| Romanova O.A. | I.М. Sechenov First Moscow State Medical University (Sechenov University) | |
| Grigoryevsky E.D. | I.М. Sechenov First Moscow State Medical University (Sechenov University) | |
| Kolchenko S.I. | I.М. Sechenov First Moscow State Medical University (Sechenov University) | |
Всего: 8
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