REGENERATIVE PROCESSES IN THE LIVER WITH THE USE OF POROUS AND COMPRESSION IMPLANTS MADE OF TITANIUM NICKELIDE

The development of medicine in the world, at present, is mainly related to the technologies of regenerative medicine. The study of regenerative processes in the liver under the influence of various factors is relevant. Titanium nickelide implants with shape memory are widely used in surgery. Recently, porous alloys based on titanium nickelide are also used as implant materials in various fields of medicine. These implant materials are biocompatible, exhibit hysteretic properties, and are permeable to biological tissues. What is fundamentally important for the development of cell and regenerative medicine techniques. In an experimental study, changes in the liver parenchyma were studied with the use of a clip to clamp the parenchymal organs and with the use of a porous implant. The possibility of targeted liver regeneration using a porous implant has been studied. The object of the study were laboratory rats with a healthy liver. The animals were operated on by applying these implants to the liver. Changes in the liver were studied 30 days after surgery by histological examination of various sections of the liver. It was established that the clip for clamping parenchymal organs did not cause tissue necrosis. A portion of the liver located at the periphery of the compression line atrophied. And in the bulk of the liver, the appearance of such signs of regeneration as enlarged and binuclear hepatocytes was noted. In the group with the use of a porous implant, no changes in the liver parenchyma were detected, nor were the phenomena of directed regeneration revealed. Thus, the experiment showed that, in comparison with a porous implant, the use of a compression clip optimizes the reparative processes in the liver. Therefore, further studies are necessary, in particular, against the background of various pathological conditions of the liver.

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