CHOICE OF THE BREAST RECONSTRUCTION METHOD IN PREVENTIVE MASTECTOMY. LITERATURE REVIEW | Issues of reconstructive and plastic surgery. 2020. № 3 (74). DOI: 10.17223/1814147/74/03

CHOICE OF THE BREAST RECONSTRUCTION METHOD IN PREVENTIVE MASTECTOMY. LITERATURE REVIEW

Рurpose: to justify the use of various methods of surgical prevention of breast cancer in women carriers of BRCA mutation. Today a large number of genes are known that are associated with an increased risk of developing breast cancer, these genes include: BRCA1, BRCA2, CHEK2, TP53, STK-11 etc. If one or another mutation is detected in a patient, the risks of developing breast cancer increase. Thus, the cumulative risk of developing breast cancer in carriers of mutations in the BRCA1 gene to 80 years old is 72%, while the risk of developing ovarian cancer is 44% and 40% the risk of developing cancer of the contralateral breast. For carriers of mutations in the BRCA2 gene, the cumulative risk of developing breast cancer is 69%, the risk of developing ovarian cancer is 17% and 26% is the risk of developing cancer of the contralateral breast. Given the significant increase in the risks of developing breast cancer with carriage of a mutation in a particular gene, today, the urgent issue is the introduction of preventive surgery into widespread practice, since it is the implementation of preventive mastectomy that can significantly reduce the risks of developing breast cancer. This review presents data from domestic and foreign literature, analyzes questions on methods of simultaneous breast reconstruction after preventive mastectomy in women with a mutation in the BRCA1 and BRCA2 genes.

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Keywords

genetically associated breast cancer, mutations in BRCA1, BRCA2 genes, surgery prevention of breast cancer

Authors

Name	Organization	E-mail
Manturova N.E.	N.I. Pirogov Russian National Research Medical University
Mistakopylo F.N.	Frau Klinik 1 LLC	filipp@mistakopulo.ru
Zikiryakhodzhaev A.D.	P.A. Hertsen Moscow Oncology Research Center - Branch of FSBI NMRRC of the Ministry of Health of Russia
Portnoy S.M.	Frau Klinik 1 LLC
Sobolevskiy V.A.	N.N. Blokhin National Medical Research Center of oncology, 24
Krochina O.V.	N.N. Blokhin National Medical Research Center of oncology, 24
Sukhotko A.S.	Moscow State University of Food Production

Всего: 7

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