NEW METHOD OF EXPERIMENTAL MODELING OF DUODENAL ULCERS IN SMALL LABORATORY ANIMALS
The experimental modeling of duodenal ulcers has not lost its relevance. The purpose of the study: experimental testing of a new method for modeling duodenal ulcer in small laboratory animals. Material and methods. The experiment involved 30 rats. Modeling of the duodenal ulcer was performed by the methodology-invasive manner and included: median mini-laparotomy, the injection of 70% acetic acid into the submucosal layer of the duodenum wall, suturing laparotomic wound. The injection was made through the animal's mouth with the help of the developed device for intra-organ intraluminal injections. The results. To obtain an ulcer with an area of 0.57 cm2 after 3 days, it is necessary to enter 0.02 ml of an acid solution, with the introduction of 0.04 ml, total necrosis of the intestinal wall occurs. Conclusion: the developed method of modeling duodenal ulcers provides a new approach to the delivery of the damaging factor to the submucosal layer of the duodenal wall and is reproducible.
Keywords
duodenal ulcer,
experimental modeling,
acetic acid,
ratsAuthors
| Poluektov V.L. | Omsk State Medical University | |
| Nikitin V.N. | Omsk State Medical University | nikitin-1966@inbox.ru |
| Khramykh T.P. | Omsk State Medical University | |
| Efanov V.P. | Omsk State Medical University | |
| Zablotskaya E.A. | City Clinical Hospital №9 | |
| Sitnikova V.M. | Omsk State Medical University | |
Всего: 6
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