Effect of long-term geomagneticfield deprivation on bioelectrical activity of brain of laboratory rats
The Earths magnetic field plays an important role in the activity of living organismsby affecting the course of physiological processes taking place in the body and, consequently, in the behaviour. The aim of the studywas to estimate the effect of long-term deprivation of geomagnetic field on brains bioelectrical activity and behaviour of laboratory rats.The geomagnetic field deprivation, which was supported at zero during 21 days, is achieved by compensation of the magnetic field of theEarth by the system of Helmholtz coils. Fluctuations of the Earths magnetic field were taken into account using a computer program thatcalculates current strength for the real time compensation solenoids. The object of the study was mature male rats (12 control rats and 12rats of the experimental group). Their behaviour before and after exposing them to the weakened geomagnetic field was assessed by theopen field test (the latent period of exit from a central square, horizontal activity, rearing, dipping, emotion, self-grooming). 6 rats of theexperimental group and 6 control group rats showed EEG and evoked potentials before and after the experiment using hypodermic needleelectrodes. The stimuli were the frequent standard (1000 Hz) and the rare deviant (500 Hz) tones with a probability of 80 and 20% respectively.We assessed the value of the mismatch negativity component, which was calculated as the difference between evoked potentials todeviant and standard stimuli. Significant changes in the behaviour of rats of both the groups in the open field test were not revealed. A significanteffect of the investigated factors on the EEG spectrum was observed. The exposition of rats in the hypogeomagnetic environmentcaused a decrease in power of the theta, alpha, beta and gamma1 bands compared with the control group. The weakening of the geomagneticfield also causes a reduction of the mismatch negativity component in evoked potentials after the experiment for the experimentalgroup of rats. Mismatch negativity is the correlate of automatic detection of any changes by means of auditory sensory system. The resultsobtained may indicate violations of the bioelectric activity of rat brain during prolonged exposition in the hypogeomagnetic environment,manifested in the sensory load, when changes in the environment occur, at least, in the auditory sensory system. The work was supported bythe Federal Goal-Oriented Program Scientific and Educational Brainpower of Innovative Russia for 2009-2013.
Keywords
гипогеомагнитная среда,
поведение,
электроэнцефалограмма,
вызванные потенциалы,
крысы,
hypogeomagnetic environment,
behaviour,
electroencephalogram,
evoked potentials,
ratsAuthors
| Khodanovich Marina Yu. | Tomsk State University | Khodanovich@mail.tsu.ru |
| Krivova Natalya A. | Tomsk State University | nakri@res.tsu.ru |
| Gul Yelizaveta V. | Tomsk State University | elizaveta-gul@yandex.ru |
| Zelenskaya Anna Ye. | Tomsk State University | an.zelenskaya@gmail.com |
| Bondartseva Natalya S. | Tomsk State University | Khodanovich@mail.tsu.ru |
Всего: 5
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