The influence of thetitanium dioxide on some functions of central nervous system of rats

The perspective of developing technology of creating and using the nanomaterials(particle size up to 100 na-nometers) attracts a big attention nowadays. Nanoparticles oftitanium dioxide (TiO2) are counted among the most widely used nanoparticles. They areused for paper, paint, ceramics, food, medicines and cosmetic consumer quality refinement.Microsize titanium dioxide is considered as biologically inactive but action degreeof nanosize titanium dioxide remains unclear. It is known for animal nervous system tobe the most respondent to different exposures. The aim of present research was estimatingof neurotropic influence of nanosize titanium dioxide. To perform this an experimenton rats was conducted. Rats were receiving a piece of attractive food with addition offixed dose of nanosize TiO2 (250 mg/kg) for 7 days.Before and after experiment behavioral activity of rats was tested in "open field"(number of squares crossed, vertical exploratory activity, head dipping, defecation andurination, center square duration). Circadian rhythm of the total locomotion activity ofrats and dynamics of the locomotion activity during the whole experiment was carriedout using the day-night camera Axis 221. In addition, spectral analysis of EEG wasperformed. EEG was recorded in the parietal cortex in unanesthetized rats using 24-channel electroencephalograph "Entsefalan-131-03" (Medicom MTD", Taganrog) in thefrequency range from 0,16 to 70 Hz. It was found that microsize and nanosize TiO2 is expressedthe neurotropic effect. The microsize TiO2 increases the total motor activity, thespectral power of the main bands of the EEG rhythms of rats, but reduces the animal'ssensibility to stress and aggressive behavior. Dioxide, in contrast, reduces the totalmotor activity, spectral power of the main bands of the EEG rhythms without affectingthe aggressive behavior of animals and sensitivity to stress.

Keywords

Authors

References