Inclusion complexes based on cyclodextrin nitrates and the possibility of using them as new drug carriers | Tekhnologii bezopasnosti zhiznedeyatelnosti – Life Safety/Security Technologies. 2023. № 3. DOI: 10.17223/7783494/3/1

Inclusion complexes based on cyclodextrin nitrates and the possibility of using them as new drug carriers

The possibility of using of nitrates of cyclodextrins as carriers of drugs has been evaluated on the example of nicorandil and isosorbide mononitrate. It is shown that nitrates of γ-cyclodextrins, in case of substitution of 8-10% OH-groups for ONO2-groups, are characterized by acceptable solubility in water and belong to moderately toxic substances according to GOST 12.1.007-76. It was found that inclusion complexes based on water-soluble nitrates of γ-cyclodextrins show synergy of antioxidant activity, which is higher than that of γ-cyclodextrin nitrate, nicorandil, their mechanical mixtures, as well as higher than that of the inclusion complex of nicorandil with γ-cyclodextrin. The authors declares no conflicts of interests.

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Keywords

cyclodextrin nitrates, inclusion complexes, toxicity, antioxidant activity

Authors

Name	Organization	E-mail
Mikhailov Yury M.	Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences	yumm@icp.ac.ru
Darovskikh Anna V.	Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences	avd@icp.ac.ru
Romanova Lyudmila B.	Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences	lbr@icp.ac.ru
Rakhimova Maria A.	Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences	nma@icp.ac.ru
Klimanova Elena N.	Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences	enklimanova@mail.ru
Faingold Irina I.	Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences	ifaingold@mail.ru

Всего: 6

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